Clinical study on cefixime granules in the field of pediatrics
Haruta, T.; Kuroki, S.; Kobayashi, Y.
Japanese Journal of Antibiotics 39(4): 1106-1114
1986
ISSN/ISBN: 0368-2781 PMID: 3761540 Document Number: 284212
The absorption and excretion and clinical effectiveness of cefixime (CFIX) granules, a new oral cephalosporin, were studied with pediatric patients with tonsillitis and urinary tract infection (UTI). 1. Peak serum concentrations in 3 children given orally a single dose of 3 mg/kg on fasting were 0.545 .mu.g/ml at 2 hours in 1 patient, and 1.56 and 1.26 .mu.g/ml at 4 hours in the other 2. The half-lives in the 3 patients were 3.21 .apprx. 3.42 hours, with an average of 3.29 hours. The urinary concentration during the first 6 hours was 36.5 .mu.g/ml in 1 patient showing the low serum level, and the first 6-hour urinary recovery rate was 7.3%. In the other 2 patients, urinary concentrations and recovery rates up to 6 hours were 87 and 62 .mu.g/ml, and 17.0 and 15.1%, respectively. The second 6-hour urinary concentrations and recovery rates were 35.5 and 20.8 .mu.g/ml, and 12.7 and 8.8%, respectively. The urinary recovery rates up to 12 hours were 29.7 and 23.9%, respectively. 2. CFIX was given orally to 19 children with 20 diseases in daily doses of 6.4 .apprx. 12.9 mg/kg in 2 or 3 divided portions for 3 to 12 days. Clinical evaluations were made on 18 diseases. Clinical effects of CFIX were excellent in 4, good in 7 and poor in 1 of the 12 patients with tonsillitis, and excellent in 5 and good in 1 of the 6 patients with UTI. The overall clinical effectiveness rate was 94.4%. 3. No side effects were observed in any of the 19 patients. Hematological tests, showed slight elevation of blood platelet counts in 2 patients. 4. The taste and odor of CFIX were well accepted by the children. 5. CFIX is a useful oral antibiotic for the treatment of bacterial infection in pediatrics. Especially, children with UTI are satisfactorily treated with CFIX at the outpatient department.