Basic and clinical studies on cefprozil in pediatrics
Kainou, Y.; Matsumoto, S.; Kida, K.; Matsuda, H.
Japanese Journal of Antibiotics 45(12): 1667-1675
1992
ISSN/ISBN: 0368-2781 PMID: 1289586 Document Number: 388508
1. Serum levels of cefprozil (CFPZ, BMY-28100) after single oral administration of 7.5 mg/kg were 2.9-5.5 micrograms/ml at 1 hour and trace at 6 hours. 2. Urinary excretion rates of CFPZ were 45.7-102.3% within 6 hours (HPLC). 3. CFPZ was administered at doses ranging 19-47.3 mg/kg/day to 17 cases of pediatric infections including 16 cases with respiratory infections and 1 case with external otitis. Good clinical and bacteriological responses were obtained in all cases. 4. As side effect, diarrhea was observed in 1 case. As abnormal laboratory test results, eosinophilia was observed in 5 cases.