Effect of DL-butylphthalide (NBP) on mouse brain energy metabolism in complete brain ischemia induced by decapitation
Feng, Y.P.; Hu, D.; Zhang, L.Y.
Yao Xue Xue Bao 30(10): 741-744
1995
ISSN/ISBN: 0513-4870 PMID: 8701729 Document Number: 454885
The effects of NBP on gasping and brain energy metabolism after complete brain ischemia in mice subjected to decapitation were investigated. The levels of ATP, phosphocreatine (PCr) and lactate were determined by the method of Lowry. The data indicated that NBP at 112.5 or 250 mg cntdot kg-1 sc can significantly prolong the duration of gasping and at the dose of 150 or 200 mg cntdot kg-1 sc reduce the level of lactate and increase the levels of ATP and PCr after complete brain ischemia. The results suggest that NBP may have brain protective action and improve ischemic brain energy metabolism.