Activation of lipid peroxidation in patients with renal hypertension
Demikhova, N.; Sukhonos, V.; Vynnychenko, L.; Psareva, V.; Prikhodko, O.
Georgian Medical News 215: 51-55
2013
ISSN/ISBN: 1512-0112 PMID: 23482363 Document Number: 668304
The study involved 53 patients with arterial hypertension in chronic kidney disease (chronic glomerulonephritis (CGN)). Lipid peroxidation was studied based on the content of diene conjugates and malondialdehyde. Protein peroxidation was studied based on the content of 2,4-dinitphenyl-aldogidrazons. The patients in all clinical variants of the CGN revealed increased activity of lipid peroxidation and the protein peroxidation, which is most pronounced in patients with nephrotic variant of CGN: increased levels of serum malondialdehyde medians occurred in 3.92 times and diene conjugates in 1.52 times (p<0.01). Increased activity of the oxidation of lipids and proteins has a negative impact on the organization of cell membranes of the renal structures and leads to loss of membrane barrier function.