Activation of lipid peroxidation: a mechanism triggering the autoimmune response
Prilipko, L.L.; Savov, V.M.; Kagan, V.E.
Acta Physiologica et Pharmacologica Bulgarica 9(4): 14-20
1983
ISSN/ISBN: 0323-9950 PMID: 6687140 Document Number: 216785
Emotional-pain stress leads to accumulation of lipid peroxidation products in rat brain tissues and to an increase in the number of antibrain antibodies against water-soluble and membrane-bound antigens in rat blood. An injection of the free radical scavenger, 4-methyl-2.6-di-tert-butylphenol to experimental animals eliminates the accumulation of lipid peroxidation products "in vivo" and completely prevents the appearance of antibrain antibodies. The activation of lipid peroxidation under stress may be regarded as a possible cause of the brain-specific antibodies release into the blood flow.