A case of advanced gastric cancer with splenic vein thrombus successfully treated with S-1 plus CPT-11 neoadjuvant chemotherapy
Taniguchi, H.; Kimura, Y.; Kim, C.; Danno, K.; Kagara, N.; Kanoh, T.; Ohnishi, T.; Tohno, T.; Nakano, Y.; Monden, T.; Imaoka, S.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 38(12): 1954-1956
2011
ISSN/ISBN: 0385-0684 PMID: 22202250 Document Number: 655705
A 63-year-old male admitted for hematemesis was diagnosed with type 3 advanced gastric cancer located in the upper and middle body of the stomach in an endoscopic examination. Abdominal computed tomography demonstrated lymph nodes metastasis and a splenic vein thrombus. Since curative resection was not deemed possible, we performed neoadjuvant chemotherapy using S-1 (120 mg, day 1-21) plus CPT-11 (135 mg, day 1 and 15) except for down-staging. After 4 courses of chemotherapy, gastric tumor and metastatic lymph nodes were reduced in size and the splenic vein thrombus was disappeared, and then total gastrectomy was performed (tub2, T2 (MP) N0 H0 M0 P0 CY0, Stage IB). S-1 medication was applied as adjuvant chemotherapy. Forty months passed from the operation, the patient remains alive with no signs of relapse.