A case of advanced gastric cancer effectively treated with paclitaxel/S-1 as neoadjuvant chemotherapy
Matsushita, H.; Honda, I.; Kato, N.; Tsuboi, K.; Okochi, O.; Kobayashi, D.; Hattori, M.; Takami, Y.; Hashimoto, R.; Takeda, S.; Mizuno, A.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(4): 647-650
2009
ISSN/ISBN: 0385-0684 PMID: 19381040 Document Number: 631069
We report a patient with advanced gastric cancer responding remarkably to neoadjuvant combination chemotherapy consisting of paclitaxel and S-1. The patient was a 65-year-old female who had large type 2 advanced gastric cancer with severe lymph node metastasis(cT3, cN3, cH0, cP0, cM0, cStage IV), treated with paclitaxel/S-1 as neoadjuvant chemotherapy. After the second course, according to UGI, gastroscope and CT findings, a significant tumor reduction was obtained. Distal gastrectomy with D2 nodal dissection were performed. The histological diagnosis was pT1, pN1, pStage IB. The histological effect of main tumor was judged to be Grade 2. The patient has now been in good health without a recurrence for 10 months after surgery. This case suggests that neoadjuvant chemotherapy with paclitaxel/ S-1 is a potential regimen for advanced gastric cancer.