A case of advanced gastric cancer successfully treated by neoadjuvant chemotherapy with CPT-11, CDDP and 5-FU
Kume, S.; Okamura, K.; Tanabe, D.; Sakaguchi, T.; Nagamoto, N.; Fukuda, S.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 26(4): 539-542
1999
ISSN/ISBN: 0385-0684 PMID: 10097754 Document Number: 498449
A patient with advanced gastric cancer was treated with combined administration of CPT-11 CDDP and 5-FU before operation. CPT-11 was given intravenously at a dose of 30 mg/m2/day on day 1 and day 8. At the same time, 5 mg/m2/day CDDP and 350 mg/m2/day 5-FU were infused for 2 weeks. The patient experienced no other adverse reaction than a mild degree of nausea. Histological examination of the resected specimen revealed complete disappearance of cancer cells both in the stomach and the regional lymphnodes.
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