A case of advanced gastric cancer with obstructive jaundice due to liver metastases successfully treated with chemotherapy
Miyazaki, Y.; Imamura, H.; Furukawa, H.; Kishimoto, T.; Ohta, K.; Nakata, Y.; Ohshiro, R.; Kamigaki, S.; Takemoto, H.; Fujimi, S.; Nakayama, T.; Fukunaga, M.; Ohsata, H.; Tatsuta, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 34(12): 2132-2134
2007
ISSN/ISBN: 0385-0684 PMID: 18219922 Document Number: 606544
We report a successful case of chemotherapy for primary far-advanced gastric cancer accompanied with poor general condition related to jaundice due to hepatic metastasis. A 54-year-old man, who had been admitted to another hospital in October 2006 with a complaint of tarry stool, was referred to our hospital. The result of detailed examination revealed an advanced gastric cancer, multiple lymph node metastases and jaundice (T-Bil 3.3 mg/dL) due to multiple hepatic metastases. The performance status (PS) was level 4. In parallel with a whole body control, a combined therapy with S-1 and CPT-11 was performed from October 27 as the first-line therapy. As a consequence of the first course, the jaundice disappeared. After the second course, the patient left the hospital. However, the patient was re-admitted to hospital in January 2007 by a reason of fever and a deterioration of PS. As exacerbation of cancerous peritonitis and the primary tumor were seen, a weekly paclitaxel therapy was performed as the second-line therapy. Two courses of treatment resulted in the disappearance of ascites and a reduction of hepatic/lymph node metastasis. PS was improved to level 0 as well. After these therapies, the patient was discharged from the hospital. As of June 2007, he continuously receives chemotherapy as an outpatient.