Convenient synthesis of optically active 2,2,2-trifluoro-1-phenylethylamine
Kato, K.; Gong, Y.; Saito, T.; Kimoto, H.
Enantiomer 5(5): 521-524
2000
ISSN/ISBN: 1024-2430 PMID: 11143816 Document Number: 6455
Amination of aryl trifluoromethyl ketones with ammonium formate readily gave racemic 2,2,2-trifluoro-1-arylethylamines in good yields. Resolution of 2,2,2-trifluoro-1-phenylethylamine was carried out with the Pseudomonas fluorescens lipase via enantioselective alcoholysis of its chloroacetamide.
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