Optically active barbiturates. Synthesis, configuration and pharmacological effects
Knabe, J.; Rummel, W.; Büch, H.P.; Franz, N.
Arzneimittel-Forschung 28(7): 1048-1056
1978
ISSN/ISBN: 0004-4172 PMID: 385006 Document Number: 127724
Optically active N-alkylated barbiturates are synthesized from disubstituted cyanoacetates. The configuration of the synthesized compounds is determined by chemical and chiroptical procedures and by X-ray analysis. In animals the barbiturates show a different anesthetic activity, in some cases the CNS activity is opposed, one enantiomer is anesthetically active, the other is a convulsive agent. In their pharmacokinetic behaviour the enantiomers show remarkable differences.