A case of advanced ampullary carcinoma successfully resected after primary chemotherapy with s-1 and gemcitabine
Ohno, T.; Koguchi, H.; Miura, A.; Tanaka, Y.; Endo, M.; Matsunaga, S.; Hasegawa, I.; Kato, A.; Tokuda, Y.; Sakakibara, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(6): 999-1002
2009
ISSN/ISBN: 0385-0684 PMID: 19542724 Document Number: 629810
The patient was a 53-year-old male who was admitted on an emergency basis with obstructive jaundice. He was diagnosed as having advanced ampullary carcinoma(T4 N0 H1, Stage IV b). To reduce the degree of obstructive jaundice, a self-expandable metallic stent was placed in the area of the biliary obstruction. Immediately after relief from obstructive jaundice, combination chemotherapy of S-1 and gemcitabine was given. Subsequently, CA19-9, the tumormarker level was reduced, the metastatic liver tumor disappeared, and the size of the primary lesion was remarkably reduced. Therefore, a curative surgical resection was done. This is a very instructive case for developing effective chemotherapy options to treat biliary tract cancers involving ampullary carcinoma.