A case of locally advanced breast cancer successfully resected after selective intra-arterial chemotherapy
Shingai, T.; Furukawa, J.; Azama, T.; Takekuni, K.; Katsumoto, Y.; Yukawa, M.; Nakaguchi, K.; Okajima, S.; Sue, F.; Hashimoto, T.; Yoshihara, W.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(12): 1819-1822
2000
ISSN/ISBN: 0385-0684 PMID: 11086420 Document Number: 516849
A 25-year-old female with a large tumor on her left breast was examined at our hospital from August, 1999. Ipsilateral supraclavicular, infraclavicular and axillary lymph nodes were swollen. She was diagnosed as having locally advanced breast cancer of stage IIIb by fine needle aspiration cytology. After the administration of docetaxel (60 mg/m2/3 weeks x 3) failed to improve her condition, we changed the treatment to selective intra-arterial chemotherapy with THP-ADR (60 mg/body/day, day 1 & 8, 41 & 48) by Seldinger's method. The target vessels were the internal thoracic, lateral thoracic, thoracodorsal and deep cervical arteries. We also combined 5-FU 500 mg/body div and CPA 500 mg/body i.v. on the same days with intra-arterial chemotherapy. As a result, the main tumor and metastatic lymph node swelling was remarkably reduced (down-staging was obtained). No recurrence was found for 5 months after curative resection.