Locally advanced pancreatic cancer successfully treated by arterial infusion chemotherapy combined with stereotactic radiotherapy--a case report
Nishiofuku, H.; Tanaka, T.; Anai, H.; Sueyoshi, S.; Yamamoto, K.; Morimoto, K.; Maeda, S.; Masada, T.; Sho, M.; Nakajima, Y.; Tamamoto, T.; Hasegawa, M.; Sakaguchi, H.; Kichikawa, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(12): 2315-2318
2010
ISSN/ISBN: 0385-0684 PMID: 21224558 Document Number: 644948
We report a 60-year-old female with locally advanced pancreatic cancer successfully treated with stereotactic radiotherapy after arterial chemoinfusion. Using the indwelling catheter-port system with the unification of the pancreatic blood supply, we initially conducted an arterial infusion of weekly high-dose 5-FU (1,000 mg/m2/qw) combined with systemic gemcitabine (1,000 mg/m2/qw). As a result, the tumor was remarkably decreased. However, a part of the tumor where the drug had not been distributed remained in no reduction. Therefore, we added the stereotactic radiotherapy (50 Gy) targeted on the limited residual tumor and combined with concurrent systemic gemcitabine (1,000 mg/m2/qw). The residual tumors have been controlled well without distant metastases, and the patient is alive today 36 months after our initial treatment.