Locoregional chemotherapy of locally advanced breast cancer in a pre-treated patient: case report
Vagliasindi, A.; Valmori, L.; Bertagni, A.; Campisi, A.; Milandri, C.; Gianpalma, E.; Calzolai, F.; Golfieri, D.R.; Verdecchia, G.M.
Tumori 89(4 Suppl): 152-154
2003
ISSN/ISBN: 0300-8916 PMID: 12903577 Document Number: 563914
We report of the use of intra-arterial chemotherapy in one case of locally advanced breast cancer, that had been systemically pre-treated. Locoregional chemotherapy was delivered via percutaneous access. The catheter tip was placed into the subclavian artery and into origin of the internal mammary artery; it was removed after every cycle of treatment. The schedule of chemotherapy was: epirubicin 30 mg/m2, mitomycin 7 mg/m2 and 5 fluouracil 1000 mg. Three cycles were administered, and the treatment was well tolerated. The patient responded to intra-arterial chemotherapy, and she subsequently underwent complete surgical resection. Intra-arterial chemotherapy for breast cancer in an uncommon approach to the treatment of locally advanced disease. Nevertheless, in selected cases, it could be a more effective therapeutic option for patients with systemic chemotherapy-resistant disease.