A clinical trial of neoadjuvant intraarterial chemotherapy for the treatment of locally advanced breast cancer
Takatsuka, Y.; Shin, E.; Kikkawa, N.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 23(11): 1523-1525
1996
ISSN/ISBN: 0385-0684 PMID: 8854796 Document Number: 461471
Seventeen patients with advanced breast cancer were treated with neoadjuvant intraarterial chemotherapy with high dose epirubicin. The following results were obtained. 1. Excellent down-staging effect (tumor reduction > 50% of its original size: 82.4%) was confirmed on primary lesions. In addition, an objective response rate of 37.5% was observed at the metastatic sites. 2. Leukopenia, which was the dose-limiting factor in this regimen, appeared at the frequency of 82.4%. Therefore, we needed G-CSF and/or a sufficient interval between each cycle. 3. A great number of cases and sufficient follow-up period will be indispensable to discuss survival in future investigation.