A Case of Liver Metastases of Ampullary Carcinoma with Clinical Complete Response Treated with Gemcitabine plus Cisplatin
Takeda, Y.; Ohmura, Y.; Katsura, Y.; Sakamoto, T.; Haruna, K.; Kawai, K.; Murakami, K.; Yanagawa, T.; Yanai, A.; Kagawa, Y.; Masuzawa, T.; Takeno, A.; Egawa, C.; Hata, T.; Murata, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 46(13): 2357-2359
2019
ISSN/ISBN: 0385-0684 PMID: 32156930 Document Number: 699131
We report a case of liver metastases of ampullary carcinoma that achieved clinical complete response after gemcitabine plus cisplatin(GC)combination chemotherapy. A 69-year-old man with obstructive jaundice was diagnosed with ampullary carcinoma and underwent laparoscopic pancreaticoduodenectomy. Postoperative histopathological examination revealed pT3aN0M0, Stage ⅡA adenocarcinoma of the papilla of Vater. Five months after surgery, multiple liver metastases were identified by CT and MRI. The patient received GC chemotherapy intravenously at doses of 1,000 and 25mg/m2 on days 1 and 8, respectively, every 3 weeks. After 3 courses of GC chemotherapy, a CT scan revealed that the liver metastases reduced in size, and PR was achieved based on the RECIST standard. However, Grade 3 neutropenia appeared. After 7 courses, the liver metastases disappeared, and the patient had achieved CR. After 9 courses, the clinical CR continued. Approximately 14 months have passed since the recurrence, and the patient is currently alive.