An acute toxicity study of bromantane
Bugaeva, L.I.; Verovskiĭ, V.E.; Iezhitsa, I.N.; Spasov, A.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 63(1): 57-61
2000
ISSN/ISBN: 0869-2092 PMID: 10763112 Document Number: 6140
The toxicity of bromantan was evaluated by conventional acute tests (according to Belen'kiĭ) and by the behavioral activity data (according to Irvin). A method of integral graphical representation of the behavioral activity data is suggested, according to which the results are plotted as a "dose trajectory." Using the dose trajectory constructed for bromantan, the levels of therapeutic, toxic, and lethal doses were calculated. It was established that catecholaminergic effects account for the mechanism of therapeutic action of bromantan, while cholinergic effects determine the drug action in toxic doses.
Document emailed within 1 workday
Related Documents
Nakamura, K.; Akutsu, S.; Matsumoto, H.; Samura, K.; Nakata, Y.; Asano, M.; Hirata, A.; Ishikawa, H.; Matsuzaki, M. 1982: Toxicological study of amikacin following intravenous drip infusion. 1. Acute toxicity in rats, rabbits and dogs, and subacute toxicity in rabbits Japanese Journal of Antibiotics 35(8): 2048-2067Badyshtov, B.A.; Losev, A.S.; Makhnycheva, A.L.; Barchukov, V.G.; Sytnik, S.I.; Pastushenkov, V.A.; Kolotilinskaia, N.V.; Mironov, S.A.; Morozov, I.S.; Seredenin, S.B. 1995: Study of heat-protective effects of bromantane at various levels of overheating Voprosy Meditsinskoi Khimii 41(2): 54-57
Grau, T.; Romero, A.; Sacristán, A.; Ortiz, J.A. 1983: CDP-choline: acute toxicity study Arzneimittel-Forschung 33(7a): 1033-1034
Hirakawa, K.; Unno, T.; Ogino, F.; Takebe, H.; Iino, T.; Nose, T. 1982: Acute toxicity study of KB-944, a new calcium antagonist Arzneimittel-Forschung 32(9): 1068-1070
Kanisawa, M.; Suzuki, S.; Kozuka, Y.; Yamazaki, M. 1977: Histopathological studies on the toxicity of ochratoxin A in rats. I. Acute oral toxicity Toxicology and Applied Pharmacology 42(1): 55-64
Newberne, P.M.; Young, V.R. 1975: An acute toxicity study with three yeast protein sources in beagle dogs Folia Veterinaria Latina 5(4): 515-526
Grekhova, T.V.; Gaĭnetdinov, R.R.; Sotnikova, T.D.; Krasnykh, L.M.; Kudrin, V.S.; Sergeeva, S.A.; Morozov, I.S. 1995: The effect of bromantane, a new immunostimulant with psychostimulating action, on release and metabolism of dopamine in the dorsal striatum of freely moving rats: a microdialysis study Biulleten' Eksperimental'noi Biologii i Meditsiny 119(3): 302-304
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Bolotina, L.A.; Lychko, N.D. 1990: The search for new antiparasitic agents. 1. the synthesis and study of the acute toxicity of new halogen-containing benzamides Meditsinskaia Parazitologiia i Parazitarnye Bolezni 6: 52-53
Romero, A.; Grau, M.T.; Villamayor, F.; Sacristán, A.; Ortiz, J.A. 1997: Toxicity of ebrotidine on reproduction. Toxicity on fertility and general reproductive performance, embryo-fetal toxicity and peri- and postnatal toxicity Arzneimittel-Forschung 47(4a): 504-510
Alonso, S.; Armijo, M.; Piña, M. 1978: Experimental comparative study of acute toxicity and gastric tolerance of eterylate, benorylate and acetylsalicylic acid Archivos de Farmacologia y Toxicologia 4(3): 349-356
Wang, J.; Jin, Y-He.; Liu, B.; Yu, Q-Lin.; Wang, K.; Zhao, C-Xia. 2008: Comparative study on the acute toxicity of pulmonary caused by nanosized and microsized powders of silicon dioxide Zhonghua Yu Fang Yi Xue Za Zhi 42(1): 30-35
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Uvarova, N.A.; Lychko, N.D.; Drusviatskaia, S.K. 1991: The search for new antiparasitic agents. 6. the synthesis and study of the acute toxicity of halogenated benzamides containing benzophenone or diphenylsulfone substitutes at the nitrogen Meditsinskaia Parazitologiia i Parazitarnye Bolezni 4: 43-44
Terazawa, K.; Watanabe, K.; Terabayashi, M.; Kuramoto, S.; Yokomoto, Y.; Otani, K.; Shimamura, K.; Yamashita, K. 1992: Acute toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) in mice, rats and dogs Journal of Toxicological Sciences 17 Suppl 4(6): 1-15
Xu, L.; Zhang, Q.-l.; Gao, F.-p.; Nie, J.-s.; Niu, Q. 2010: Cell toxicity assessment methodologies applied in the study of the toxicity of nano-alumina to nerve cells Zhonghua Yu Fang Yi Xue Za Zhi 44(9): 785-789
Shankar, T.N.; Shantha, N.V.; Ramesh, H.P.; Murthy, I.A.; Murthy, V.S. 1980: Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guineapigs & monkeys Indian Journal of Experimental Biology 18(1): 73-75
Mikhaĭlitsyn, F.S.; Lebedeva, M.N.; Kozyreva, N.P.; Lychko, N.D.; Drusviatskaia, S.K.; Uvarova, N.A. 1991: The search for new antiparasitic agents. 3. the synthesis of haloid-containing sulfonamidobenzamides with a benzo-2,1,3-thiadiazole radical in the sulfonamide group and a study of their acute toxicity Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 36-38
Schunior, A.; Zengel, A.E.; Mullenix, P.J.; Tarbell, N.J.; Howes, A.; Tassinari, M.S. 1990: An animal model to study toxicity of central nervous system therapy for childhood acute lymphoblastic leukemia: effects on growth and craniofacial proportion Cancer Research 50(20): 6455-6460
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Lebedeva, M.N.; Kovalenko, F.P.; Dzhabarova, V.I.; Lychko, N.D.; Baiandina, D.G.; Naĭdenova, A.S. 1991: The search for new antiparasitic agents. 8. the synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines Meditsinskaia Parazitologiia i Parazitarnye Bolezni 5: 55-57
Viatleva, O.A.; Barchukov, V.G.; Morozov, I.S.; Salenko, I.A.; Zhirnov, E.N. 2000: The neuro- and psychophysiological effects of bromantane Voenno-Meditsinskii Zhurnal 321(8): 61
De Castro, J.; Van de Water, A.; Wouters, L.; Xhonneux, R.; Reneman, R.; Kay, B. 1979: Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34 995. III. Comparative study of the acute metabolic toxicity of the narcotics used in high and massive doses in curarised and mechanically ventilated dogs Acta Anaesthesiologica Belgica 30(1): 71-90