An acute toxicity study with three yeast protein sources in beagle dogs
Newberne, P.M.; Young, V.R.
Folia Veterinaria Latina 5(4): 515-526
1975
ISSN/ISBN: 0301-0724 PMID: 1241778 Document Number: 89759
Candida tropicalis (CBS 6373) and C. lipolytica (CBS 6331) were grown on n-paraffins or gas oil substrates and evaluated as single-cell proteins by feeding to beagle dogs to provide 25% crude protein on a dry weight basis, the other nutritional requirements being given at levels known to be adequate for the spp. No adverse clinical or biochemical reactions occurred, although weight gain, probably associated with reduced feed intake due to unpalatability, was lower in dogs given the yeasts alone than in others given the yeasts and casein. Post-mortem examinations revealed renal lesions, consisting of absorbed protein in the epithelium of the proximal tubules, mineralized casts and epithelial proliferation causing blockage of tubules. The lesions were found only in dogs fed on diet in which nucleic acids had been reduced with ammonium hydroxide. It is emphasized that although yeasts grown in this way support growth, care should be taken in the selection of processing methods to ensure their safety.
Document emailed within 1 workday
