Accumulated occurrence of a necrotising panosteitis of the jaw bones in Beagle dogs
Strasser, H.; Brunk, R.
Deutsche Tierärztliche Wochenschrift 78(10): 304-307
1971
ISSN/ISBN: 0341-6593 PMID: 4931181 Document Number: 32794
Among a total of about 4,000 descendants of a male and three female Beagles used to start a breeding colony for research animals, 21 cases of the condition appeared (6 males, 15 females) at about 1 year (8-19 months) of age. The first signs were increased salivation, reduced food intake, strong carious mouth odour. Within a short time the saliva was seen to be mixed with blood and/or detritus. Inspection revealed necrosis of the gums and alveolar regions at the back of the jaws, usually the lower jaw. As the result of an extensive dystrophic process the whole jaw bones eventually necrosed entirely. No bacteria were isolated from affected regions. A similarity with the course of chronic phosphorus poisoning in human beings was noted. All the cases descended either directly from the original pairing of the male with its sibling or from descendants of the other two original pairings crossed with those of the first pair. The number of offspring of crossings in which the disease occurred was 278, making an incidence of 7.6%. One male sired 13 of the affected animals in crossings with five bitches, one its sister (all four female offspring of this pairing, but not the two males, were affected).