Interferon-stimulating activity of muramoyl dipeptide glycosides
Zholobak, N.M.; Spivak, N.I.; Zemliakov, A.E.; Tsikalov, V.V.; Chupakhina, T.A.; Kur'ianov, V.O.; Chirva, V.I.
Mikrobiolohichnyi Zhurnal 69(4): 33-39
2007
ISSN/ISBN: 0201-8462 PMID: 17977450 Document Number: 608580
The uninvestigated interferon (IFN)-inducing capacity of glycoside derivatives of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP) has been studied. Most MDP glycosides tested in vitro were more active than the reference preparation MDP. Under the in vivo conditions three studied preparations: MDP, a-heptyl-MDP and beta-(2-methyl-3-phenylchromonyl-7)-MDP stimulated production of considerable amount of circulating IFN that evidences for the promising character of their further investigation as preparations immunostimulators.