The stimulating action of lipopolysaccharide and muramyl dipeptide on the activation of mononuclear cells in human peripheral blood by recombinant interleukin-2 in vitro
Rakhmilevich, A.L.; Pelevina, M.A.; Artsimovich, N.G.; Fuks, B.B.
Biulleten' Eksperimental'noi Biologii i Meditsiny 106(12): 698-701
1988
ISSN/ISBN: 0365-9615 PMID: 3061497 Document Number: 307502
Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) were effective in augmentation of killer cells generation from human peripheral blood mononuclear cells (PBMC) in response to recombinant human interleukin-2 (IL-2). Pretreatment of PBMC with combination of LPS and MDP resulted in most significant their proliferation stimulated by IL-2. Thus our results show the enhancement of PBMC sensitivity to IL-2 by action of LPS, MDP and most of all by their combination in vitro.