Inhibitory activity of isorhamnetin glycosides from Calendula officinalis L. on the activity of lipoxygenase
Bezákova, L.; Masterová, I.; Paulíková, I.; Psenák, M.
Die Pharmazie 51(2): 126-127
1996
ISSN/ISBN: 0031-7144 PMID: 8720810 Document Number: 459144
Three isorhamnetin flavonoid glycosides, CAl 1-3, were isolated from the flowers of C. officinalis and investigated for their inhibitory effect on lipoxygenase from rat lung cytosol. All compounds were enzyme inhibitors, with Cal 1 (1 sugar unit) showing the strongest activity, and Cal 3 (3 sugar components) showing the lowest activity. The inhibitory effect of Cal 2 on lipoxygenase was very similar to that of the reference compound, rutin . It is suggested that isorhamnetin flavonoid glycosides are active antiinflammatory principles of C. officinalis.