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Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation

Robak, J.; Shridi, F.; Wolbís, M.; Królikowska, M.

Polish Journal of Pharmacology and Pharmacy 40(5): 451-458

1988

ISSN/ISBN: 0301-0244
PMID: 3151014
Document Number: 309702
Thirty nine flavonoids, isolated from plants, were tested in respect of their influence on soybean lipoxygenase activity, cyclooxygenase activity and inhibition of ascorbic acid-stimulated malonaldehyde formation in liver lipids. Almost all of the tested compounds were antioxidants and stimulated cyclooxygenase when arachidonic acid was used as a substrate at a concentration of 100 microM. Eleven flavonoids were inhibitors of soybean lipoxygenase. A good correlation between the chemical structure and the tested activity was observed. The most active compounds in all tests were luteolin, 6-hydroxyluteolin, nepetin, quercetagetin, patuletin and myricetin.

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