Studies on separation, appraisal and the biological activity of 5-HMF in Cornus officinalis
Ding, X.; Wang, M.-Y.; Yu, Z.-L.; Hu, W.; Cai, B.-C.
Zhongguo Zhong Yao Za Zhi 33(4): 392-396; 484
2008
ISSN/ISBN: 1001-5302 PMID: 18533494 Document Number: 626858
To develop the mechanism of improving protection function of prepared Cornus officinalis for liver and kidney and the biological activity of 5-hydroxymethylfurfural (5-HMF). Pharmacological and chemical studies were used to choose active part. A compound from active part was separated and appraised. To investigate his biological functions, pharmacological experiment was actualized. A component was separated and identified. His is 5-HMF. 5-HMF can protect human vein epidermal cell against H2O2 and glucose and inprove acute liver injury in mice. 5-HMF is the active component in prepared Cornus officinalis and substance basis for protecting liver and kidney.