The antiviral activity of RNAse Bacillus intermedius in experiments with mice preinfected with street rabies virus
Gribencha, S.V.; Potselueva, L.A.; Barinskiĭ, I.F.; Balandin, T.G.; Deev, S.M.; Leshchinskaia, I.B.
Voprosy Virusologii 49(6): 38-41
2004
ISSN/ISBN: 0507-4088 PMID: 15597960 Document Number: 582608
The Bacillus intermedius RNAse, when administered once and according to 11 repeated experiments, protected the CBA mice preliminarily infected with street rabies virus (protection, 40-67%; P<0.01-0.001). The animals were protected when B. intermedius RNAse was intramuscularly administered at the site where the rabies virus was introduced. It was not effective when it was injected in the brain, vein, under the skin or in the muscles of a non-infected extremity. Neither did it produce any suppressive effect on vaccinal antirabies immunity.