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Effect of gangliosides on the resistance of mice to the rabies virus

Krasnopol'skiĭ, I.M.; Shvets, V.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 104(12): 698-699

1987

ISSN/ISBN: 0365-9615
PMID: 3689963
Document Number: 299531
The survival of animals has been studied after their infection with a mixture of rabies virus and gangliosides isolated from various organs. It has been found that virus incubation with a summarized fraction of cerebral gangliosides increased considerably the survival of animals. At the same time it was shown that gangliosides from cattle spleen and red blood cells taken in the same proportions as cerebral gangliosides, do not have any protective effect. The in vivo study of the antiviral ganglioside activity has been performed.

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