Comparative study of the antiviral activity of pancreatic and microbial RNAse
Alekseeva, I.I.; Kurinenko, B.M.; Kleiner, G.I.; Skuia, A.Z.; Penzikova, G.A.
Antibiotiki 26(7): 527-532
1981
ISSN/ISBN: 0003-5637 PMID: 6267996 Document Number: 169282
The efficacy of pancreatic RNase with microbial enzymes (RN-ases) of Act. rimosus and Bacillus intermedius) was studied comparatively in vitro in a transplantable cell culture of the swine embryokidney with respect to the aphthosa virus (AV) and the virus of the Aujeszky disease (VAD). The VAD proved to be most sensitive to RNases. RNase of Bac. intermedius showed the highest antiviral efficacy. The enzymes were active in vivo, when the albino mice and newborn rabbits were infected with the AV, the RNase of Bac. intermedius being also most active in this case.