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Study of mutagenic activity of hexachlorocyclohexane and products of its microbial degradation

Iutyns'ka, H.O.; Iamborko, N.A.; Pindrus, A.A.

Mikrobiolohichnyi Zhurnal 72(6): 18-22

2010

ISSN/ISBN: 0201-8462
PMID: 21381312
Document Number: 639116
Mutagenic activity of hexachlorcyclohexane (HCH) was investigated. As is known, gamma-isomer of HCH has insecticidal properties. The strains of microorganisms of genera Pseudomonas, Stenotrophomonas, Bacillus decomposing HCH into 46.3-86.7% from initial quantity have been selected. Microbial HCH destruction by investigated strains made changes of pesticide genetic activity: in most cases in condition of intermediate action the quantity of mutations S. typhimurium TA 100 and S. typhimurium TA 98 have decreased 1.2-1.5 times in comparison with initial substance. In a single case after HCH transformation by strain P. putida 1 the intermediates have increased the mutation frequency 1.9 times. The obtained results are necessary for selection of the most promising strains-decomposers as a basis of biopreparations for remediation of HCH polluted soils.

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