Clinical regularities of the interaction of pancreatic and microbial RNase with cells in vitro
Kurinenko, B.M.; Kupriianov-Ashin; Kalacheva, N.V.
Antibiotiki i Khimioterapiia 38(1): 28-33
1993
ISSN/ISBN: 0235-2990 PMID: 8060180 Document Number: 420610
The kinetics of interaction of exogenic RNAses with isolated cell culture of the human amnion FL was studied in a mathematical model. It was shown that by a number of kinetic parameters the pancreatic RNAse had higher affinity to the cells which quite agreed with higher cytotoxicity of the enzyme as compared to that of the microbial RNAse in regard to the cell culture.