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Interaction of Immune Lymphocytes in Vitro with Normal and Neoplastic Tissue Cells

Brondz, B.D.

Folia Biologica 10: 164-176

1964

ISSN/ISBN: 0015-5500
PMID: 14164363
Document Number: 3147
Immune lymphocytes obtained by immunizing different strains of mice with homologous sarcoma cells, when washed and transferred to monolayer cultures of these sarcomas and donor macrophages, adhere to the cells of the culture and destroy them in 2-4 days. The immunological specificity of this phenomenon was demonstrated and the effect was determined qualitatively and quantitatively. The phenomenon depends on the dose of lymphocytes and is effected in the absence of complement and immune serum only by living cells immune to strong (but not weak) transplantation antigens. The dynamics of the activity of immune lymphocytes in vitro and of the humoral antibody titer after one and several immunizations were studied. Findings are given which indicate that the cytotoxic effect of immune lymphocytes in vitro is not related either to humoral or cytophil antibodies. The relation of these results to previous findings on the role of lymphocytes in immunity is discussed.

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Interaction of Immune Lymphocytes in Vitro with Normal and Neoplastic Tissue Cells

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