Thermodynamic considerations of the interaction between caffeine and paracetamol in aqueous solutions
Okore, V.C.; Osuji, A.C.
Bollettino Chimico Farmaceutico 140(5): 345-350
2001
ISSN/ISBN: 0006-6648 PMID: 11680089 Document Number: 538686
Caffeine interacts physically with paracetamol thus producing changes in some physicochemical properties of paracetamol. There is evidence that the interaction may be in the form of a 1:1 association complex. Complexation of caffeine and paracetamol leads to increases in the aqueous solubility of the later. Thermodynamic influences play significant roles in the stabilization of the formed complex.