Chemical protein synthesis methods in drug discovery
Kochendoerfer, G.G.
Current Opinion in Drug Discovery and Development 4(2): 205-214
2001
ISSN/ISBN: 1367-6733 PMID: 11378960 Document Number: 531955
The applicability of chemical protein synthesis over the last five years has been greatly expanded by significant increases in the size (up to 600 amino acids) and variety of accessible proteins, including new classes of proteins such as phosphoproteins, glycoproteins and integral membrane proteins. Chemical protein synthesis has also produced novel high-throughput screening and biosensor technology, and exciting lead compounds for the generation of powerful synthetic protein pharmaceuticals.