Peptoid drug discovery: the choice of scaffolds for combinatorial chemistry/HTS and subsequent substitutions for parallel synthesis/lead optimization
Wood, P.L.
Current Opinion in Drug Discovery and Development 1(1): 34-40
1998
ISSN/ISBN: 1367-6733 PMID: 19649787 Document Number: 493060
Document emailed within 1 workday
Related Documents
Beeley, N.; Berger, A. 2000: A revolution in drug discovery. Combinatorial chemistry still needs logic to drive science forward Bmj 321(7261): 581-582Crespo, A.; Rodriguez-Granillo, A.; Lim, V.T. 2017: Quantum-Mechanics Methodologies in Drug Discovery: Applications of Docking and Scoring in Lead Optimization Current Topics in Medicinal Chemistry 17(23): 2663-2680
Jain, A.N. 2004: Virtual screening in lead discovery and optimization Current Opinion in Drug Discovery and Development 7(4): 396-403
Oyelere, A.K. 2010: Macrocycles in medicinal chemistry and drug discovery Current Topics in Medicinal Chemistry 10(14): 1359-1360
Ross, B.; Tran, T.; Bhattacharya, P.; Watterson, D.Martin.; Sailasuta, N. 2011: Application of NMR spectroscopy in medicinal chemistry and drug discovery Current Topics in Medicinal Chemistry 11(1): 93-114
Kim, T-Jeong.; Chang, Y. 2013: Imaging agents in medicinal chemistry and drug discovery Current Topics in Medicinal Chemistry 13(4): 409-410
Chang, G.; Ruggeri, R.B.; Harwood, H.James. 2002: Microsomal triglyceride transfer protein (MTP) inhibitors: discovery of clinically active inhibitors using high-throughput screening and parallel synthesis paradigms Current Opinion in Drug Discovery and Development 5(4): 562-570
Korfmacher, W.A. 2003: Lead optimization strategies as part of a drug metabolism environment Current Opinion in Drug Discovery and Development 6(4): 481-485
He, W.; She, P.-W.; Fang, Z.; Guo, K. 2013: The research progress of dynamic combinatorial chemistry Yao Xue Xue Bao 48(6): 814-823
Hoekstra, W.J.; Poulter, B.L. 1998: Combinatorial chemistry techniques applied to nonpeptide integrin antagonists Current Medicinal Chemistry 5(3): 195-204
Zhou, S.-b.; Wang, J.; Liu, H. 2016: Lead compound optimization strategy(5) – reducing the hERG cardiac toxicity in drug development Yao Xue Xue Bao 51(10): 1530-1539
Siest, G.; Delwaide, P.; Malya, P.A.G.; Breuer, H.; Galteau, M.M.; Salway, J.G.; Tognoni, G.; Tryding, N. 1988: International Federation of Clinical Chemistry, Scientific Committee: Drug interferences and drug effects in clinical chemistry. Part 6. Laboratory tests in monitoring drug administration Journal of Clinical Chemistry and Clinical Biochemistry 26(3): 181-186
Kochendoerfer, G.G. 2001: Chemical protein synthesis methods in drug discovery Current Opinion in Drug Discovery and Development 4(2): 205-214
Badillo, J.J.; Hanhan, N.V.; Franz, A.K. 2010: Enantioselective synthesis of substituted oxindoles and spirooxindoles with applications in drug discovery Current Opinion in Drug Discovery and Development 13(6): 758-776
Kojima, H.; Okabe, T.; Nagano, T. 2013: Open innovation center for drug discovery: a research-supporting network for drug discovery Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 141(6): 327-332
Fujita, Y. 2013: Innovation by TaNeDS (Take a New challenge of Drug diScovery) collaborative drug discovery project Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 142(2): 89-95
Blondelle, S.E.; Crooks, E.; Ostresh, J.M.; Houghten, R.A. 1999: Mixture-based heterocyclic combinatorial positional scanning libraries: discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans Antimicrobial Agents and ChemoTherapy 43(1): 106-114
Thunus, L.; Lapiere, C.L. 1975: Synthesis and pharmacologic properties of some hydroxyethylpiperazinylpyridines (substitutions at 2-3 and 3-4) Annales Pharmaceutiques Francaises 33(12): 663-669
Shen, Y. 2007: Discovery on Target 2007--CHI's Fifth Annual Conference. RNAi for Drug Discovery and Therapeutics IDrugs: the investigational drugs journal 10(12): 848-850
Young, S.S. 1999: Discovery 99: accelerate and improve the drug discovery process. 26-29 April 1999, San Diego, CA, USA IDrugs: the investigational drugs journal 2(7): 648-649