Chemical synthesis of polar zipper peptides: motifs for potential protein association in inherited neurodegenerative diseases
Johnson, T.
Biomedical Peptides Proteins and Nucleic Acids Structure Synthesis and Biological Activity 1(4): 247-249
1995
ISSN/ISBN: 1353-8616 PMID: 9346840 Document Number: 453935
Syntheses of peptides containing contiguous repeats of glutamine or asparagine, related to sequences derived from proteins associated with neurodegenerative diseases, are described. Such homo-polymeric peptides are notoriously difficult to prepare due to the formation of aggregated structures during their solid phase synthesis. A novel approach using a randomized array of side chain protected and unprotected residues proved to be an effective strategy for preventing intermolecular peptide-chain association.