Quantitative determination of selected tricyclic biological active compounds by using capillary electrophoresis
Kurzawa, M.; Dembiński, B.; Szydłowska-Czerniak, A.; Sandra, P.
Acta Poloniae Pharmaceutica 56(6): 415-417
1999
ISSN/ISBN: 0001-6837 PMID: 10715886 Document Number: 502920
Five tricyclic antidepressants: imipramine hydrochloride, noxiptilin hydrochloride, hydroxyzine dihydrochloride, diethiazine hydrochloride and amitryptyline hydrochloride were determined by the capillary electrophoresis method. The determinations were performed by using a fused sillica capillary (60 cm x 50 microns i.d., effective length 53 cm). Acetate buffer (25 mM ammonium acetate and 1 mM acetic acid) in (1:1) methanol:water solution was used as an electrolyte. The determination voltage was 20 kV. The UV-detector at 214 nm was applied.