Top Abstract Purchase Related
Home
>
Node
>
Subnode

The anti-ischemic properties of new specific bradycardic agents, derivatives of 2-mercaptobenzimidazole

Chichkanov, G.G.; Tsorin, I.B.; Kirsanova, G.I.

Eksperimental'naia i Klinicheskaia Farmakologiia 61(6): 20-24

1998

ISSN/ISBN: 0869-2092
PMID: 9929811
Document Number: 496748
Experiments on narcotized cats demonstrated that the derivatives of 2-mercaptobenzimidazole possessing the properties of specific bradycardic agents and coded as CM-251, CM-266, and CM-345, reduce the mean rise of segment ST on numerous leads of the epicardial electrogram during 5-min occlusion of the anterior descending branch of the left coronary artery. The agents stabilize the heart pumping and contracting functions under conditions of 30- and 60-min reperfusion of the coronary artery, respectively. It is concluded on the grounds of the obtained data that the 2-mercaptobenzimidazole derivatives possess a marked anti-ischemic action.

Document emailed within 1 workday
Secure & encrypted payments

Chichkanov, G.G.; Tsorin, I.B.; Kirsanova, G.I.; Berdiaev, S.I.; Turilova, A.I. 1997: Anti-arrhythmic properties of specific bradycardic agents from the group of 2-mercaptobenzimidazole derivatives Eksperimental'naia i Klinicheskaia Farmakologiia 60(5): 35-39
Chichkanov, G.G.; Tsorin, I.B.; Kirsanova, G.Iu.; Berdiaev, S.Iu.; Khorunzhił, V.A. 1997: Derivatives of 2-mercaptobenzimidazole--a new group of specific bradycardic drugs Eksperimental'naia i Klinicheskaia Farmakologiia 60(3): 23-26
Gross, G.J.; Daemmgen, J.W. 1986: Beneficial effects of two specific bradycardic agents AQ-A39 (falipamil) and AQ-AH 208 on reversible myocardial reperfusion damage in anesthetized dogs Journal of Pharmacology and Experimental Therapeutics 238(2): 422-428
Auclair, C.; Schwaller, M.A.; René, B.; Banoun, H.; Saucier, J.M.; Larsen, A.K. 1988: Relationships between physicochemical and biological properties in a series of oxazolopyridocarbazole derivatives (OPCd); comparison with related anti-tumor agents Anti-Cancer Drug Design 3(2): 133-144
Safonova, E.V.; Zharova, E.A.; Samoĭlenko, L.E.; Sergienko, V.B. 2003: Preliminary data on combined assessment of tolerance to exercise, left ventricular contractile function in ischemic heart disease patients taking bradycardic agents Terapevticheskii Arkhiv 75(4): 29-33
Gout, B.; Jean, J.; Bril, A. 1992: Comparative effects of a potassium channel blocking drug, UK-68,798, and a specific bradycardic agent, UL-FS 49, on exercise-induced ischemia in the dog: significance of diastolic time on ischemic cardiac function Journal of Pharmacology and Experimental Therapeutics 262(3): 987-994
Tian, S.L.; Zhao, S.W.; Zhu, A.T.; Fang, Y.; Li, K.Q. 1993: Studies on anti-tumor agents. I: Synthesis and anti-cancer activity of amino acid derivatives of norcantharidin Yao Xue Xue Bao 28(11): 870-875
Shvarev, I.F.; Tsetlin, A.L. 1972: Anti-blastic properties of berberine and its derivatives Farmakologiia i Toksikologiia 35(1): 73-75
Senova, Z.P.; Lyskovtsev, V.V.; Grigor'eva, E.K.; Gorbunova, V.V.; Kaverina, N.V. 1986: Anti-arrhythmia and antifibrillatory properties of dibenzazepine derivatives Kardiologiia 26(8): 24-28
Mosaad, M.S.; Mohsen, K.M.; Emad, K.M.M.; Abotaleb, N.; Salwa, N.M.; Marwa, A.F. 2010: Novel 6,8-dibromo-4(3H)-quinazolinone derivatives of promising anti-inflammatory and analgesic properties Acta Poloniae Pharmaceutica 67(2): 159-171
Vigorita, M.G.; Previtera, T.; Trovato, A.; Monforte, M.T.; Barbera, R.; Bisignano, G. 1989: N-trifluoroacetyl derivatives as pharmacological agents. IV--Antiinflammatory and related properties; antimicrobial activity of some polyaromatic trifluoroacetamides Farmaco 44(2): 173-184
Nasyrov, K.M. 1987: Antioxidant properties of anti-inflammatory agents Farmakologiia i Toksikologiia 50(6): 113-116
Dauksas, V.; Gaidelis, P.; Udrènaitè, E.; Kuliesius, V.; Labanauskas, L. 1994: Synthesis and anti-inflammatory properties of 1,2-dialkoxy-4-(3-dimethylaminopropionyl)benzenes and their 5-halogeno derivatives Arzneimittel-Forschung 44(7): 835-839
Sharma, A.; Gupta, S.P.; Siddiqui, A.A. 2013: A QSAR study on a series of thiourea derivatives acting as anti-hepatitis C virus agents Indian Journal of Biochemistry and Biophysics 50(4): 278-283
Mavel, S.; Rubat, C.; Coudert, P.; Privat, A.M.; Couquelet, J.; Tronche, P.; Bastide, P. 1993: Synthesis of new 5-substituted pyrazolo[1,5-d][1,2,4]-triazine derivatives and their analgesic, anti-inflammatory and antipyretic properties Arzneimittel-Forschung 43(4): 464-468
Aupetit, J.F.; Timour, Q.; Chevrel, G.; Omar, S.; Loufoua-Moundanga, J.; Faucon, G. 1993: Comparative study of different classes of anti-arrhythmia agents on the vulnerability of ischemic ventricular fibrillation Therapie 48(4): 403-407
Roubal, Z.; Grimová, J.; Nĕmecek, O.; Cepelák, V. 1972: Effects of nonsteroid anti-inflammatory agents and some dicoumarol derivatives on platelet aggregation, fibrinolysis and stabilization of cell membrane in vitro Acta Universitatis Carolinae. Medica. Monographia 53: 229-235
Paperno, A.A.; Kovalev, G.V.; Gurbanov, K.G. 1991: The anti-ischemic properties of verapamil and its effect on myocardial functional potentials in coronary artery occlusion Farmakologiia i Toksikologiia 54(2): 26-28
Counillon, L.; Scholz, W.; Lang, H.J.; Pouysségur, J. 1993: Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties Molecular Pharmacology 44(5): 1041-1045
Lumholtz, I.B. 1981: Drug information: agents for the treatment of arrhythmias. Therapeutic main group: anti-arrhythmia agents. 16. (3). Anti-arrhythmia agents with action on ventricular arrhythmias Sygeplejersken 81(2): 15