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Anti-arrhythmic properties of specific bradycardic agents from the group of 2-mercaptobenzimidazole derivatives

Chichkanov, G.G.; Tsorin, I.B.; Kirsanova, G.I.; Berdiaev, S.I.; Turilova, A.I.

Eksperimental'naia i Klinicheskaia Farmakologiia 60(5): 35-39

1997

ISSN/ISBN: 0869-2092
PMID: 9483403
Document Number: 478530
It was shown in experiments on aconitine, calcium chloride, and epinephrine models of heart rhythm disorders that derivatives of 2-mercaptobenzimidasole possessing the properties of specific bradycardiac agents coded as SM-251, SM-266, and SM-345 cause a marked antiarrhythmic effect. SM-266 and SM-345 reduce considerably the number of ventricular fibrillations and the life-hazardous arrhythmia occurring during 7-min occlusion and subsequent reperfusion of the coronary artery in anesthetized rats. The agents under study reduced the ectopic heart rate in Harris' conscious dogs. It is concluded that the studied 2-mercaptobenzimidasole derivatives exert a marked antiarrhythmic and antifibrillatory effect.

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