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Anti-arrhythmia and antifibrillatory properties of dibenzazepine derivatives

Senova, Z.P.; Lyskovtsev, V.V.; Grigor'eva, E.K.; Gorbunova, V.V.; Kaverina, N.V.

Kardiologiia 26(8): 24-28

1986

ISSN/ISBN: 0022-9040
PMID: 3761845
Document Number: 271327
Antiarrhythmic and antifibrillation properties of bonnecor, a derivative of dibenzepin, were studied in comparison with ethmozine, quinidine and novocainamide, using various experimental arrhythmia models. Bonnecor activity was somewhat smaller than that of ethmozine, and much greater than that of quinidine and novocainamide in the mixed atrioventricular arrhythmia model simulated in aconitin-treated rats and the ventricular arrhythmia model simulated by two-degree coronary occlusion in dogs. Intravenous 1 mg/kg and oral 6 mg/kg bonnecor doses prevented ventricular fibrillation caused by acute coronary occlusion in rats, while ethmozine showed no such effect.

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