The anti-arrhythmia activity and effect on the heart conduction system of the new anti-arrhythmia preparation bonnecor

Sokolov, S.F.; Golitsyn, S.P.; Malakhov, V.I.; Bankuzov, V.A.; Koltunova, M.I.; Golitsyn, L.S.

Farmakologiia i Toksikologiia 53(3): 57-60

1990


ISSN/ISBN: 0014-8318
PMID: 2387385
Document Number: 349098
In 10 patients with frequent ventricular extrasystoles there were studied the antiarrhythmic effectiveness and side effects of a new drug bonnecor at a single intravenous administration in doses from 15 to 60 mg (0.17-0.91 mg/kg). It was found that the drug exerted the antiarrhythmic effect at dosages of over 0.4 mg/kg and side effects and toxic effects occurred at dosages of over 0.7 mg/kg. The optimal dose for a single intravenous administration was regarded to be the dose of 0.6 mg/kg. The mechanisms of action of bonnecor were studied during intracardiac electrophysiological investigation. The drug was shown to suppress the conduction of excitation along the atrioventricular node, the His-Purkinje system, the ventricular myocardium and the abnormal pathways of conduction. Thus, bonnecor may be referred to as an agent of class I according to the classification of Vaughan Williams. When administered intravenously (0.6 mg/kg) bonnecor was found to interrupt and prevent the recurrent development of atrioventricular tachycardia and also supraventricular tachycardias at the presence of the abnormal pathways of conduction.

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