Derivatives of 2-mercaptobenzimidazole--a new group of specific bradycardic drugs
Chichkanov, G.G.; Tsorin, I.B.; Kirsanova, G.Iu.; Berdiaev, S.Iu.; Khorunzhił, V.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(3): 23-26
1997
ISSN/ISBN: 0869-2092 PMID: 9324391 Document Number: 469503
Experiments on anesthetized cats and rats showed that 2-mercaptobenzimidazole derivatives, known as SM-266 and SM-345, induced marked and long-term bradycardia, increased the stroke output, and reduced the requirements of the heart for oxygen. The drugs had practically no effect on systemic arterial pressure, cardiac output, and heart contractility. Studies on isolated frog venous sinuses disclosed that bradycardia induced by the drugs under study was related to the decrease caused by them in the velocity of slow diastolic depolarization directly in the pacemaker cells of the sinus node. On grounds of the obtained results it is concluded that the drugs under study may be related to a new group of specific bradycardiac agents.