The anxiolytic effect of the new 2-mercaptobenzimidazole derivative in MR and MNRA rats
Seredinin, S.B.; Viglinskaia, I.V.; Kolik, L.G.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(3): 3-5
1997
ISSN/ISBN: 0869-2092 PMID: 9324393 Document Number: 478632
The effect of the new drug SM-346, a derivative of 2-mercaptobenzimidazole, on the behavior of inbred MR and MNRA rats, differing in the phenotype of the emotional-stress reaction in the open field test was studies. In the Vogel conflict test SM-346 in a dose of 1 mg/kg produced an anxiolytic effect in MR rats but had no effect on the behavior of MNRA rats. The obtained results allow the conclusion that SM-346 possesses a selective anxiolytic action.
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