Anxiolytic-like effects of group i metabotropic glutamate antagonist 2-methyl-6- (phenylethynyl) -pyridine (MPEP) in rats
Kłodzińska, A.; Tatarczyńska, E.; Chojnacka-Wójcik, E.; Pilc, A.
Polish Journal of Pharmacology 52(6): 463-466
2000
ISSN/ISBN: 1230-6002 PMID: 11334240 Document Number: 520441
We examined the anxiolytic-like activity of2-methyl-6-(phenylethynyl)-pyridine (MPEP) using the conflict drinking Vogel test in rats as a model. MPEP is a selective and brain-penetrable mGlu5 receptor antagonist, the most potent compound described so far. The results indicate that MPEP produced a dose-dependent anticonflict effect in rats. These data suggest that selective mGlu5 receptor antagonists may become a new class of anxiolytics.
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