Effect of novel anxiolytic agent aphobazole on coherence of the brain biopotentials in MR and MNRA rats
Kozhechkin, S.N.; Sviderskaia, N.E.; Korol'kova, T.A.; Koshtoiants, O.K.; Kozhedub, R.G.; Seredenin, S.B.
Eksperimental'naia i Klinicheskaia Farmakologiia 64(4): 3-6
2001
ISSN/ISBN: 0869-2092 PMID: 11589104 Document Number: 527909
Effect of the anxiolytic drugs afobazole, diazepam, and chlordiazepoxide on the cortical biopotential coherency was studied in MR and MNRA rats with increased and decreased level of emotionality, respectively. Afobazole increased a difference in the biopotential coherency between rats of the two lines in the range of EEG theta, alpha, and beta rhythms. In the subrange of dominating theta activity (6.00-7.25 Hz), this effect took place at the expense of reduced coherency in MNRA rats in the absence of changes in the MR line. Afobazole decreased the biopotential coherency in the alpha activity band (7.5-8.25 Hz) in the rats of both lines. This is indicative of the presence of a CNS-stimulating component in the pharmacological activity spectrum of afobazole. The expediency of using afobazole in patients with different levels of anxiety is discussed.