A case report of preoperative intra-arterial infusion chemotherapy for pancreatic head carcinoma
Ohigashi, H.; Ishikawa, O.; Sasaki, Y.; Nakano, H.; Nakamori, S.; Kameyama, M.; Hiratsuka, M.; Kabuto, T.; Furukawa, H.; Yasuda, T.; Imaoka, S.; Fujita, M.; Kuroda, C.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 24(12): 1825-1828
1997
ISSN/ISBN: 0385-0684 PMID: 9382542 Document Number: 483220
Intra-arterial infusion chemotherapy was given preoperatively to one patient with pancreatic head adenocarcinoma, in order to prevent local failure after surgery. Under an angiographic procedure, a catheter was placed in the gastroduodenal artery after embolizing the right gastric artery and gastroepiploic artery. Before surgery, 5-fluorouracil (250 mg/day) had been continuously infused for 2 weeks and bolus infusion of methotrexate (25 mg) with 5 micrograms of angiotensin-II had been performed every 3 days. As a results, the maximum diameter of the pancreatic tumor decreased from 3 cm to 2 cm on the CT-Scan. An extended pancreatoduodenectomy with portal vein reconstruction was performed. In histologic study, degenerative tumor cells were shown not only in the primary tumor but also in the extrapancreatic perineural invasion.