A case of life-threatening anaphylactoid reaction caused by povidone-iodine
Nakao, M.; Nakatani, K.; Suyama, H.; Maekawa, T.; Nakagawa, M.; Hanaki, C.; Kawaguchi, R.
Masui. Japanese Journal of Anesthesiology 46(1): 105-109
1997
ISSN/ISBN: 0021-4892 PMID: 9028092 Document Number: 483221
A 64 year-old man developed life-threatening anaphylactoid reaction caused by povidone-iodine during induction of anesthesia for elective coronary artery bypass graft surgery. While he had a history of cardiac arrest caused by iodine, he could tolerate contrast material and povidone-iodine for preoperative coronary angiography with pretreatment of H-1 and H-2 receptor blockades and methylprednisolone. During the operation and postoperative care we could manage cardiac failure by continuous monitoring of cardiac output (CCO) using pulsed-thermodilution method. We recommend prophylactic use of H-1 and H-2 receptor blockades for surgical patients who may be at risk for anaphylaxis or anaphylactoid reaction.