Serologic diagnosis of acute infectious mononucleosis
Sević, S.
Medicinski Pregled 50(9-10): 403-408
1997
ISSN/ISBN: 0025-8105 PMID: 9471540 Document Number: 483219
This paper deals with data on 48 patients with diagnosis of infectious mononucleosis hospitalized at the Clinic for Infectious Diseases in Novi Sad in the period October 1995 to October 1996. Tests like Paul-Bunnell-Davidson's, Monospot and ELISA were performed on samples of acute serum taken from every patient. Analyzing these results it has been established that majority of patients were 16-20 years of age, that the disease occurs in both sexes equally, and that most patients had a severe clinical picture with a typhoid form of the disease. Paul-Bunnell's test was positive in 50.49% of patients, Monospot in 56.25%, while all 48 patients had positive IgM EBV VCA. 11 patients had a positive IgG EBV VCA too, while none of the examined patients was IgG EBV NA positive. Statistical analysis revealed a statistically significant difference in reliability of diagnosis made by specific serologic tests and tests which confirm the existence of heterophile antibodies. Characteristic changes of the differential blood picture, such as lymphomonocytosis with virocytes have been found only in 28 (58.33%) patients, so that in diagnosis of this disease hematological findings must be questioned.