Activity of the enzymes of ethanol and acetaldehyde metabolism in rats with varying initial sensitivity to alcohol
Bardina, L.R.; Satanovskaia, V.I.; Pron'ko, P.S.; Kuz'mich, A.B.
Ukrainskii Biokhimicheskii Zhurnal 69(1): 94-99
1997
ISSN/ISBN: 0201-8470 PMID: 9454388 Document Number: 474200
The experiments were carried out on male rats with different sensitivity to alcohol. To assess sensitivity to ethanol effects, we have used ethanol-induced sleep time and variations in rectal temperature of alcohol-intoxicated animals. Activity of alcohol dehydrogenase, microsomal ethanol-oxidizing system, catalase and aldehyde dehydrogenase in the liver as well as ethanol and acetaldehyde levels in the blood were determined after alcohol intoxication (3.5 g/kg, i.p., 8 days). The development of alcohol tolerance was accompanied by induction of the microsomal ethanol-oxidizing system in long-sleeping rats and in short-sleeping rats as well as by an increase in ethanol and acetaldehyde levels in the blood.