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Activity of key enzymes of heme metabolism and the content of several hemoproteins in the liver of rats of various ages

Kaliman, P.A.; Nikitchenko, I.V.

Ukrainskii Biokhimicheskii Zhurnal 61(1): 75-78

1989

ISSN/ISBN: 0201-8470
PMID: 2741245
Document Number: 345114
The activity of key enzymes of heme metabolism (delta-aminolevulinate synthase, EC 2.3.1.37, and heme oxygenase, EC 1.14.99.3) and the content of some hemoproteins were examined in the liver of male Wistar rats aged 1, 3 and 24 months. It is established that the activity of delta-aminolevulinate synthase decreases when rats reach the age of 3 months and remains at the same level in rats aged 24 months. The content of microsomal cytochrome P450 and the activity of tryptophan-2,3-dioxygenase holoenzyme increase when rats reach the age of 3 months. The total tryptophan-2,3 dioxygenase activity is higher in animals aged 24 months as compared to those aged 1 month. The heme oxygenase activity and the content of microsomal cytochrome b5 do not change with age.

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