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Analysis of the pharmacokinetics of ethanol injected intraperitoneally and intravenously in rats with different levels of initial alcohol motivation

Vlasova, N.V.; Rodionov, A.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 104(7): 57-59

1987

ISSN/ISBN: 0365-9615
PMID: 3620652
Document Number: 299069
Ethanol pharmacokinetics was studied after its intraperitoneal and intravenous administration in rats with different initial level of alcohol motivation using gas chromatography. It was shown that in general pharmacokinetic pattern studied upon both intraperitoneal and intravenous ethanol administration (with respect to resorption and/or distribution), the rate of ethanol elimination including a number of processes leading to a decreased drug content may be an important criterion for the selection of animals with distinct initial levels of alcohol motivation.

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